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KMID : 0923620150150040191
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Immune Network
2015 Volume.15 No. 4 p.191 ~ p.198
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Immune-mediated Liver Injury in Hepatitis B Virus Infection
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:Oh In-Soo
:Park Su-Hyung
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Abstract
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Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.
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KEYWORD
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Hepatitis B Virus, Pathogenesis, Immune response
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